2011ִҵҩʦҩѧרҵϰժҪʮ(4)
Դ 2011823
: 2011ִҵҩʦҩѧרҵϰժҪʮ(4)ҩﶯѧģ͡
ʮ ҩﶯѧ
Ľ ģ͵Ѫҩ
ѪҩڷעֱҩȡѪҩҩսڵٶȽӽһٶȹ̡ҩΪһٶȹ̡
1. ѪҩŨȷҩﶯѧ
ģѪҩַǣ
dX/dt=KaXa-KXKaΪһٶȳXaΪղλҩ
C=KaFX0 (e-Kt-e-Kat)/ [V(Ka-K)]
2. ҩﶯѧ
A ٶȳK
ka>>kʱlgC=(-k/2.303)t+lg[ kaFX0/V(ka-k)]
lgCtͼɵõһĩΪֱߵĶߣֱбʿkֱƣֱཻĽؾΪlg[kaFX0/V(ka-k)]
B ٶȳ
òжɵã
lgCr=(-ka/2.303)t+lg[kaFX0/V(ka-k)]
ʽCrΪŨ
lgCrtͼΪһֱߣֱбkaɽؾV
C ʱѪҩŨȵ
ʱΪtmax=2.303lg(ka/k)/(ka-k)
tmaxkak
ŨΪCmax=(FX0/V)e-ktmax
CmaxX0
D
ѪҩŨ-ʱµAUCҩﶯѧҪ
AUC=FX0/KV
F ʵ CL=FX0/AUC
G ͺʱto
Ƽ
رƼ
ࣺdrfcy