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46. ӣѡԻøҩ
47. ̩ɺǻ̩ɣͪѡԻøҩиҩøյãɼйӦжҪƷʪԺʪԹؽסƼʹ磬Ҳڼ˿没Ѫ没ķȡӦθӦˮ͹Ӧҩ໥ãյҩøǿ߰ĴлͨѪ׽ϲλǿ㶹ڷѪҩڷѪҩӢɺƤʼصá
48. ǿPGϳøҩĿ׽ȺʹáڼԷʪԹؽסʹԹؽ׼֢ʹ񲡡ԡ񲡡֧ܲиá
49. ѡյͻøҩ
50. ʹҩжӡ̩ɡҡͪҡ˫ȷᡢ
51. ȫҩ顢顢ѡ顢ǵȰͪԴ
52. ʧҩû1.2.ıĤӦԼԶ۷3.ıERPЧӦڣͶλʱ̣APD۷IA໹б֡ŵIB໹ɡ׿ᡢֶIC໹жᡣIII໹аIV໹еض׿յض
53. ᶡļϸĤ֬׽ϣĤơӵͨ͸ԣΪĤȶɽԣӳERPϦͿáٴԺԹĶٶЧ԰˥ӦػơӦҪθӦƷӦѪѹѪ˨Ķͣᶡʺ͹Ӧļ𺦡ضȷҴ͡ǿ߰жѪػ߽á˥ѪѹΡܲȫá
54. ³򰷣׿ʧҩҪĶ/Ƶ粫ӦθӦӦǴ͡Ѫѹ˥á
55. ࿨ҪʧɽԣAPDӳERP,ı䲡ٶȡʧЧ
56. ͪڷԻԹ粫עֹԻĶٺԤۺ֢Ķ١ʧЧ˥Ķ͡Ѫѹ߽áͬҩǶᡢͿᡢᡣ
57. ǰԴ
58. ͪ׿ʧҩڷĶٺʧӦĶ
59. ׿ҩάףڷտ죬׹ЧӦԡļϸĤͨCaҪӰ񼷿ͷҽӦϸɣʧĶѡڰйIJѪѹߡҪθȲӦ˥͡ԭݿ˼ѪѹȽá
60. ׿ҩƽ֬ǿڷѸգи׹áѪƽļϸCaʹѪͣѪѹ½ļͣŹ״״ΣӹļٴڷĽʹɵڸѪѹӦԭݿˡѪѹĹܲá
61. ׿ҩض׿ڷãܸ׹Ӱ졣Ϊ׿ҩŹ״Ѫܣʹͣʹ񼷿ἰҽԽ͡ڹIJĽʹơἰжȸѪѹҲнϺЧ겡ˡ2ϷҴ͡Ѫѹ˥߼иá
62. ĹܲȫѪ˥ߣҩҩǿգЧػƶ߰ЧظЧë߰Cȥë߰ë߰Kûƣǿ߰ԼҪϸĤϵNa,K-ATPøʹϸڸӡҩãǿԼɣļԵӰ죨ҴԣӳЧӦڣٴӦãĹܲȫʧķ˶Ķ٣˥ķ˶ԷӦΣҪΪθϵͳࡣʧüƳЧӢɺ࿨ȶǿ߰ĹʧdzЧǿ߰ĶͿðƷơаũ߸ŨȣũͰͷӶ
63. Ѫѹҩƽ֬ǿڷѸգи׹áѪƽļϸCaʹѪͣѪѹ½ļͣŹ״״ΣӹļٴڷĽʹɵڸѪѹӦԭݿˡѪѹĹܲá׿໹άס׿ͪῨƽƽѪܽתøƼеǿȵĽѹãΪѪܽתøӶѪܡȩͪڣơڸ͸ѪѹΪᡢжԭԻ͸Ѫѹѡҩصǽ͸ѪѹߵѪתҷʺءѪܽϵͳŵɳ̹ɳ̹ɳ̹ѪܽII׿ҩڸ͸ѪѹΪ
1.1
2.1
3.4.ͻǰĤ2塣ѹûȺжȸѪѹٷλԵѪѹҩѪҩÿǿЧ˥֧˽áֶԽѹҩѹǿʹжȸѪѹпƫͷʹԼ۵ƣҲʹҩߵĽ䶾׻ͣƿֶʺԸѪѹܲߡҩáѪƽĤʹ֮ʧȥȡʹNEDAӶʹڵʵĺϳɺʹ𽥼٣ºĽߡ򾲺Ͱáоʷ߽áणĩȡŨĩʹĩĤȶӶֹͷŲѹáӦλԵѪѹຣѹҩڸѪѹºͣײҩԡµѪأӦʵءຣһ˹ϳɵܦ1ҩᡢжȸѪѹ԰ܲ߸ΪáƣѪŽѹҩΪͷNOѪźѪСۼѹǿѸٶݡ뾲ΣܿڷҪƸѪѹΣҲڳѪ˥ߣļм׻͡ĪᶨѪƽडມɳມɶ׶ມຣͨżŵضͪɫ֣5-ɫ׿ǰлغϳɴٽԴ
64. ĽʹҩͣûƣɲNOƽҩãŹ״еƽáҪžʹѪ٣ݻĩѹұͣ͡ٴӦãƺԤĽʹӦͷʹλԵѪѹעƼ󻹿Ѫ쵰Ѫ֢ɾעԿѪѹۼ­ѹ߽á׿ض׿յض˫״ĪпѪСãͪҶض׿ڹIJĽʹƣἰжȸѪѹҲнϺõЧ겡ˡʧЧάסҴ͡Ѫѹ˥߼иá
65. Ӳҩ
һ Ѫ֬ҩ
1. HMG-CoAԭøƼ工͡øƵ̴ϳٶȣѪLDL-Cˮƽ½õĵѪ֬ãܽTCLDL-C,ʼԡڼԻǼԸߵ̴Ѫ֢͡շ͡͡
2. ֭ϼϩѡΪߵ̴Ѫ֢ڿڷڵ֭ϡڳ뱽ͱסມػƶ߰״ءڷѪҩ֬άҩADEKҶᡢijЩؽϣӰЩҩպЧӦáп沴ϰ
3. ȱأȱǿ֬øLPLĻԡVLDLTG,HDL,ѪСۼٴҪTGΪĸ֬Ѫ֢зŵآءDZȡ
4. ᣺ٴࣩͨ;Ӱ֬׵ĴлҪΪVLDLIJƸ֬Ѫ֢ѪƫͷʹͷʹԶѪ˨˨ڶѣ֢˵ȡаĪ˾򲡡ʹ硢ιȫߡ
ҩ޲TCLDL-CTGVLDLӰ졣Ҫͨʡٴڸ֬Ѫ֢II͡رڴͼԸߵ̴Ѫ֢ߡĿǰеʹ併LDL-Cʹɫ˵ҩVEVC,ҪкǿĿԡ
ϩ֬
1. w-6ϩ֬᣺뵨̴ϲתΪ֭ųпѪСѪܵáٴڸ֬Ѫ֢Ӳ
2. w-3ϩ֬ʮ̼ϩ᣺Ƹϳ֬ʺ֬׵ãܴٽ̴йɷֹӲٴڸ֬Ѫ֢Ӳ͹IJ
ġ Ұ̴ֹڶڳ֬ʹɣѪСۼҪڸ֬Ѫ֢TCTGLDLVLDLԸ༲иЧеøøEơ
66. ҩ߻ף߻૱ᡢ򣩣ֶ֧εơءͬתϵͳȻƺˮաѪؼۺ֢ԼжúѪãٴˮףԷˮ׺ˮףԤ˥ߣ˥ˣٶųҪڱͱסˮࡢ廯жӦУˮңΣθӦԵȣظܲȫ򲡡ʹ缰СãߵѪ֢иáຣԶСܽˣơתϵͳȻƺˮնµѪءҩáѹúͿáٴӦˮ׵ѡҩѪѹ֢ӦңµѪأעⲻҪżҩǿ߰⻯ɵɺãɵʧӦʱءӲ߽ãѪ֢ʹ综áܲȫѪǣ򲡻߽ãӦणԶСԶ˺ͼϹܣֱѡͨƵգʹųӶ򡣰Ѫá¶֯ˮãѪ͸áٴӦԤ˥ߣˮ׼ۡĹܲȫߺ߽áҩ򰷡ɽ洼Դ
67. ƶѪҩҶᡢVB12
68. ѪҩͿѪҩάKѪҩǺϳѪøԭѪӵıʡάKȱ֢ҩѪƵ׳ĵʹаױᡢ׻ᡣأѪҩΪӰάɣ⻹пסѪСۼѪճȼáڷѪ˨˨ԼɷֹѪ˨γɺѪѪ֢ĸڡ³ѪһӦͣҩ㾫׶ԿܲȫظѪѹԳѪǼĤ׵IJˡиѪѲߡ˫㶹أҪڷѪ˨Լ׳Ѫͬءơ˨øøҪڼѪ˨˨Լ׼Ӵ󸺺ҪӦΪѪ͹øǰлء˫״ĪɿĽʹड̵ҩȻ李N-װᡢ强µȣҩɴ򡢿ȱȣƽҩءƼءɫơͪҡɡƷȡ
69. ϵͳҩ
1. ͨ⡪ءATPø̼ơ̼ơƽM壬θڣͨ⡪ءATPøγɱĤ飨γɱĤĻءùء
2. ҩθøøø
3. ֹҩհͪµ¡
4. кҩþơ̪ࡢҺʯ͡Դ
5. ֹкҩطŵҩ̿߶ʽ̼顣
6. ҩȥ⵨ᡢȥᡣ鰷ҩ H1ͼп鰷áááٴڱ̬Ӧζ֢Ż¡ʧߡӦΪ˯ȡH2׿ҩҪ涡涡Ī涡ȡҪ
70. ӹƽ˷ҩأҪǿӹٴʹ߲ԼѪҪ˷ӹѪܡٴڲӹԭӹѪƫͷʹڴ߲ѪӲ״ߡǰء
71. ƤʼأЧɵɡ⻯ɵɡЧɡɵȡЧɡɵȡƤʼأȩͪȥƤͪżأƤʹܼˡ

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