2ߵ
߱㹻йع涨Ҫ1824Ҫʱ
αƼ
öȺЧовαƼաαƼİȫԺЧӦúϸαƼѡԭΪоöоʱѡеľעΪαƼöȻЧоʱӦѡͬƷΪαƼ
Ƽ
ƼӦΪٴӦķŴƷṩܳȡȶԡЧ۵ݡҩṩྦྷͼѧ칹ϡ
ģ
ƼһΪƼһΪαƼͨ˫ƼƣԵںӰ졣ֳ飬һȷƼòαƼһȷòαƼƼ֮ΪϴڣϴӦҩ10˥ڣͨΪ1ܻ2ܡ
3ƼƼһαƼʱ˲3Ƽ3ڵĶ3×3ʽơÿ֮ϴͨΪ1ܻ2ܡ
ȡ㣺ȡƶĿɿҪáҩǰȡհѪһѪҩŨ-ʱӦࡢֲࡣһѪҩŨ-ʱ߷ǰȡ4㣬ȡ66ϵĵ㣬ʱ丽Ӧ㹻ȡ㣬ܲհף12㡣ȡ35˥ڻѪҩŨΪCmax1/101/20.
ڲѪҩŨȲⶨʱɲƷвⶨҺҩƷ鷽ӦöȲⶨҪҽѧ Ѽ
壩ҩȷ
öЧоʱҩһӦٴҩһ¡ƼͲαƼӦõȼʹòȼʱӦ˵ԭҩڴ˼ΧڷԶѧɣöʱӦԼУ
о
߽ʳҹ10Сʱϣڴ糿ոƼαƼ250ml¿ˮͷҩ2Сʱˮ4Сʱͳһ͡ڷҩҪڲͬʱȡѪҪȡѪѪѪȫѪ䶳棬⡣߷ҩһȡѪٴнСвӦʱӦӦʩҪʱӦֹͣ顣
ߣҩﶯѧ
õĸ߲ͬʱƷѪҩŨݼƽֵбͼȻֱԸ߽йҩﶯѧ㣬ƽֵͱҪҩﶯѧΪ˥ڣt1/2ŨȣCmaxʱ䣨TmaxѪҩŨȪʱAUC.CmaxTmaxʵֵʾơAUC0tn㵽tʱѪҩŨ-ʱηη㣬tnһοɲŨȵȡʱ䡣AUC0ޣ㵽ʱѪҩŨ-ʱʽ㣬AUC0=AUC0tn+Ctn/z.CtnһѪҩŨȣzĩٶȳt1/2=0.693/zzöѪҩŨȪʱĩֱֵ߲бá
ö飬ҪʱղѪ㣨AUC0tn/AUC0ޣ×100%80%.
ˣöȼ
1θҩ
öFӦøߵAUC0tnAUC0ֱ㣬ֵƼTͲαƼRͬʱ
F=AUC0tnT/AUC0tnR×100%F=AUC0ޣT/AUC0ޣR×100%
ҩҩﶯѧʱƼͲαƼҲɲòͬʽУ
F=AUC0tnT×DR/AUC0tnR×DT×100%F=AUC0ޣT×DR/AUC0ޣR×DT×100%
ʽУDRΪαƼĸҩDTΪƼĸҩƼͲαƼҩļӦʵ⺬㡣
лݣǰҩҩڴл죬ⶨѪԭҩʱɲӦĻԴлöо
öȵļAUC0tnΪοAUC0ޡ
2θҩ
£ɿǶθҩ̬̬ѪҩŨȹöȣ1ҩճ̶ٶнϴ죻2öȸ3͡Ƽ4θҩԭҩлŨȺܵͣӦķȷá
θҩȼӣҩ̬ijһҩʱڣβɼƷҩŨȣ̬ڼ0ʱѪҩŨ-ʱµAUCSSƼͲαƼʱʽö
F=AUCSSTAUCSSR×100%
ʽУAUCSSTAUCSSRֱƼαƼ̬µAUC.
ţЧۣҩﶯѧͳƷ
ӦҩﶯѧҪAUCCmaxͳƷЧۡͳƷȽAUCCmaxݽжתȻз˫t鴦ƼAUC90%ڲαƼ80%125%ΧڣCmaxڲαƼ70%143%ΧڣΪƼαƼЧTmax÷Dzм顣
Ϊ˱ЧԱȽϣÿһ߷òͬƼҩﶯѧAUCCmaxӦƽбҪгƼTͲαƼR֮ıֵT/RͱֵĶ˼ǵֵ⣬Ӧü㼸ξֵӦðڱС
ʮٴ桢úͲӦ
߲ʷͻԼоصĿܸúͲӦӦ档