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Ŀ߿ո£ȽƼαƼʺճ̶ȣȷԻ͡ƼαƼǷΪЧл͡
1Ҫѡ
ͬͨƼ
2αƼ
һӦѡùͬеĻ͡ƼƷΪαƼϵµĻ͡ƼӦѡеͬͨƼƷΪαƼ
3
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4ṩ
1гߵѪҩŨ-ʱݡѪҩŨƽֵбͼ
2ҩﶯѧƽֵCmaxTmaxAUC0tnAUC0Fṩƽʱ䣨MRTȡ
3ٴ桢úͲӦͨƼҪͬ
5Ч
Ի͡ƼαȻ͡ƼȽϣAUCCmaxЧҪTmaxͳӦ죬ΪƼЧԻ͡ƼͨƼȽϣAUCЧҪͬͨƼAUCЧۣΪճ̶ЧCmaxͣTmaxӳţͳƷһָ겻ЧʱƼлͻ
θҩ˫ڽ
ĿоԻ͡ƼαƼθҩ̶̬Լ̬ѪҩŨȵIJ
1Ҫѡ
ͬ£ɼõߡΪ1824ҪʱʵӡαƼͬθҩ
2Ƽ
ƷηƼαƼƼⶨҩͷÿ1ҩƼӦڿո10СʱԺҩҩʳ24Сʱÿ2εƼӦո10СʱԺҩҩʳ24СʱڶӦڲǰͺ2Сʱҩҩʳ2Сʱÿ250ml¿ˮͷһҪҩ12СʱˮͨƼΪαƼʱҩ뷽Ӧ뻺͡Ƽÿܼȡ
3ȡ
ҩʱپ7˥ںⶨ3ĹŨȣCminȷѪҩŨǷ̬ȡðڲͬͬһʱ䣨һ峿ԵʱҩѧӰ죬ұڱȽϡ̬һڣյθҩʱƣȡ㹻Ѫ㣬ⶨü̬ѪҩŨȪʱݣйصҩﶯѧŨȡʱ䡢̬ƽѪҩŨȣCavAUCSSȡ
4ҩﶯѧݴ
1гߵѪҩŨȪʱݡѪҩŨƽֵбͼ
2ߵCmaxCminTmaxCavAUCSSƽֵCmaxTmaxʵֵCminһ㰴һҩǰʱʵŨȵƽֵ㣬AUCSSη㡣
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Cav=AUCSS
ʽУAUCSS̬ڼ0ʱѪҩŨ-ʱµǷҩʱ䡣
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5ͳѧЧ
뻺͡ƼθҩķҪͬ
6ٴ桢úͲӦ
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